To further investigate the hub genes contributing to the recurrence of AM, we performed a deep learning analysis based on our scRNA-seq datasets.30 Strikingly, EZH2 was again identified as one of the most critical driver genes for the recurrence of AM (Fig. 7a), which strengthens our hypothesis that EZH2 may be an effective therapeutic target for AM. Here, EZH2 is linked to acute myeloblastic leukemia with maturation.