Cells in c0 expressed high levels of CXCL8, HLA-DRA, HLA-B, HLA-C, B2M, and IL1B, indicating an epithelial cell with immune features, which was also observed in nasopharyngeal carcinoma.20 and our previous study on murine head and neck squamous cell carcinoma.14 Gene ontology (GO) analysis and gene set variation analysis (GSVA) analysis showed that the immune response was mainly correlated with this subset of cells (Fig. S3A, B), implying their potential function in modulating the tumor immune microenvironment of AM. The gene discussed is B2M; the disease is nasopharyngeal carcinoma.