Angiotensin II leads to SIRT1 and CAT downregulation and vascular senescence, which is achieved by inducing prolonged lysine acetylation of PGC-1α and interrupting the PGC-1α-FOXO1-SIRT1 feed-forward.419 PGC-1α deficiency can also mediate impaired autophagy caused by the downregulation of SQSTM1 (autophagy receptor), thus accelerating vascular aging and atherosclerosis.423. The gene discussed is PPARGC1A; the disease is atherosclerosis.