Endothelial-specific overexpression of PGC-1α remarkably impedes endothelial to mesenchymal transition of pulmonary arterial endothelial cells and reduces vascular muscularization, thereby attenuating the development of pulmonary hypertension.742 With the development of drug screening technologies and targeted drug delivery systems, further investigations will facilitate improved applications of PGC-1α in clinical treatment. The gene discussed is PPARGC1A; the disease is pulmonary arterial hypertension.