PPARGC1A and skin cancer: Melanoma is one of the most common and aggressive skin cancers and continues to be a great contributor to cutaneous cancer-related mortality.326 It has been observed that two subpopulations of cells, one expressing high levels of PGC-1α and a second subpopulation with very low PGC-1α expression, exist in melanoma.327 Tumors expressing high levels of PGC-1α are associated with lower survival compared to tumors with low PGC-1α expression.