ESRRA and breast cancer: It has been reported that the inhibition of PGC-1β decreases the glycolytic pathway, increases ROS generation, and impairs cell proliferation.310 Similarly, the suppression of PGC‐1β inhibits BC cell growth, proliferation, and migration, and promotes apoptosis by cooperating with the transcription factor FOXA2 or hexokinase domain component 1.311,312 Deblois et al. found that ERRα can be recruited to specific sites at chr.17q12 to regulate the expression of ERBB2 in human BC cells and PGC-1β is recruited to ERRα-bound segments in the chr.17q12 amplicon.