At first, Kunej et al. found that the AA genotype of the Gly482Ser polymorphism is related to 1.9-times increased risk of T2DM and is considered as a risk factor for the development of T2DM in Caucasians.628 The PGC-1α Gly482Ser allele can also predict the conversion from impaired glucose tolerance to T2DM.629 Then, over two decades, the researchers conducted a large number of studies. This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.