PPARGC1A and atherosclerosis: Overexpression of PGC-1α in bone marrow-derived macrophages diminishes foam cell formation, whereas macrophage-specific deletion of PGC-1α accelerates atherosclerosis in the LDLR-/- mouse.419 Methyl-transferase-like 3 (METTL3) acts during ox-LDL-induced monocyte inflammation.