PPARGC1A and Alzheimer disease: However, Dumont et al. illuminated that overexpressing PGC-1α in Tg19959 transgenic mouse exacerbates Aβ and tau accumulation, accompanied by an impairment of proteasome activity.448 These paradoxical conclusions reflect that maintaining the delicate balance between PGC-1α expression and its function plays crucial roles in the inhibition of AD and contributes to the design of treatments.