PPARGC1A and amyotrophic lateral sclerosis: PGC-1α expression increases mitochondrial energy-producing capacity, thereby making more ATP available for sustained muscle activity.485 PGC-1α overexpression dramatically improves motor function and survival, accompanied by reduced blood glucose level and by the protection of motor neuron loss, restoration of mitochondrial electron transport chain activities, and inhibition of stress signaling in the spinal cord.486 So far, there are relatively few explorations on the detailed underlying mechanisms regarding PGC-1α in ALS, substantially more studies should be initiated in the future.