Mechanistically, cold-inducible Foxj3 stimulates the expression of PGC-1α and UCP1, subsequently promoting energy expenditure.591 The transcription factor GATA3 mitigates obesity by activating thermogenesis and improving energy expenditure through the upregulation of UCP-1 expression via its interaction with PGC-1α.592 TFEB is a basic helix-loop-helix transcription factor. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.