PPARGC1B and obesity due to melanocortin 4 receptor deficiency: Consequently, less fat is accumulated and stored.128 In 3T3-L1 adipocytes, overexpression of PGC-1β improves insulin sensitivity and mitochondrial function.176 In contrast to this, adipose-specific ablation of PGC-1β impairs thermogenesis and reduces the number of contacts between mitochondria and lipid droplets.596 These findings demonstrate that PGC-1β contributes to the control of energy balance and provide a potential approach for developing novel anti-obesity drugs.