PPARGC1A and cancer: Although colorectal cancer (CRC) was infrequently diagnosed several decades ago, it has been the fourth most deadly cancer in the world, with almost 900, 000 deaths annually nowadays.278 Previous research primarily considered PGC-1α as a predictor of lymph node metastasis and poor prognosis in human CRC.279–281 Recently, accumulating compelling evidence has emphasized the sophisticated molecule network regarding the roles of PGC-1s in CRC.