PPARGC1A and diabetic kidney disease: CKD is characterized by a reduced kidney filtration function, accompanied by nephron loss, inflammation, and extracellular matrix deposition.513 With a huge global burden and a prevalence of 10-14%, CKD is now considered a public health priority.514 The important roles of PGC-1α in CKD, especially diabetic kidney disease (DKD) and kidney fibrosis, have been noted.