ESRRA and cancer: A single-factor logistic regression analysis confirmed that PGC-1α and ERRα may serve as novel biomarkers for predicting the risk of advanced myometrial invasion.606 Similarly, increased levels of PGC-1α in BC patients are correlated with more aggressive cancer characteristics, as well as poorer disease-free survival and overall survival in comparison to patients with lower plasma levels.607 Additionally, in CRC, there is a significant correlation between PGC-1α expression and nodal metastasis.