Atherosclerosis is a chronic inflammatory and lipid-depository disease of the arterial wall and is a leading cause of acute cardiovascular events and death worldwide.404 One case-control survey reported that Gly482Ser polymorphism in the gene encoding PGC-1α contributes to the risk of coronary artery disease.405 Meanwhile, the PGC-1α protein is markedly downregulated in human atherosclerotic vessel samples.80 These remind the potential effects of PGC-1α in atherosclerosis. Here, PPARGC1A is linked to atherosclerosis.