PPARGC1A and Huntington disease: While the minor allele of SNP rs7665116 (g.38570 C), located in the transcribed gene region, is linked to a delay in disease onset, the minor allele of SNP rs2970870 (g.-1437C) in the promoter region contributes to an earlier onset of HD in its homozygous state.626 Interestingly, no relation between PGC-1α Gly482Ser polymorphism and oxidative stress biomarker levels is detected in ALS patients under resting conditions.