PPARGC1A and neoplasm: Melanoma proliferation is enhanced by acquiring mitochondria from tumor-supporting MDSCs, while the suppression of PGC-1α reduces mitochondrial transfer from MDSCs to melanoma.330 Besides, approximately 30.4-66.0% of cutaneous melanomas are attributed to BRAF mutation.331 The researchers illustrated that BRAF activation is associated with decreased oxidative enzymes, diminished mitochondrial quantity and function, and increased production of lactate and BRAF triggers this metabolic reprogramming via the suppression of PGC-1α and MITF, a melanocyte lineage factor.332