PPARGC1A and metabolic disease: Meanwhile, two mitochondrial lipid transporters, CPT-1 and CPT-2, are strongly induced in mixed skeletal muscle and several transcriptional regulators (ERRα, NRF-1, and PGC-1β) are decreased without altering metabolic gene expression.746 This suggest that a mutation of PGC-1α promoter increases resting metabolism, translating into an enhanced mitochondrial oxidative capacity and FAO in adult zebrafish muscle.746 Therefore, zebrafish may serve as unique biomedical models for the investigation about the roles of PGC-1s in metabolic disorders.