p53 is a tumor suppressor gene with extensive and powerful functions, known as the “guardian of the genome”.344 Li et al. found that p53 downregulates the expression and nuclear localization of the PGC‐1α protein and stimulates mitochondrial dysfunction, which promotes apoptosis, highlighting PGC‐1α as an essential target of p53-induced apoptosis in prostate cancer cells.345. This evidence concerns the gene PPARGC1A and Familial prostate cancer.