PPARGC1A and non-small cell lung carcinoma: The PGC-1α-positive group has reduced overall survival compared to the PGC-1α-negative group, suggesting that PGC-1α represents a biomarker for nodal metastasis and poor prognosis.279 In contrast to the above conclusions, high levels of PGC-1α in non-small cell lung cancer are indicative of a positive prognosis.