PPARGC1A and Familial prostate cancer: Prostate cancer remains the most frequently diagnosed non-skin malignancy that affects men’s health and 1 in 25 men globally is diagnosed with this malignant condition during their lifetime.339 According to data from the TCGA cohort, several well-established factors, that are associated with prostate cancer progression risks, have been identified, notably PPARGC1A.340 It is worth noting that PGC-1s also act as a double-edged sword in prostate cancer.