Selective activation of PGC-1β within hepatocytes can prevent liver lipid overload and fibrosis by inducing mitochondrial OXPHOS, FAO and citrate cycle.239 The forkhead box protein subfamily member FOXA2 regulates glucolipid metabolism and is closely correlated with hepatic steatosis and NAFLD.602 Notably, PGC-1β can coactivate with FOXA2 and modulate hepatic lipid homeostasis. The gene discussed is PPARGC1B; the disease is fatty liver disease.