Importantly, transgenic expression of PGC-1α4 in muscle reduces the loss of muscle mass and strength and improves glucose homeostasis during cancer progression, thereby dramatically ameliorating cancer-induced cachexia.262 In addition, transgenic expression of PGC-1α4 in skeletal muscle induces VEGF in vivo, whereas the knockdown of PGC-1α4 abrogates the induction of angiogenesis in response to hypoxia.265 A recent investigation revealed that PGC-1α4 partially modulates the metabolic benefits of resistance exercise. The gene discussed is VEGFA; the disease is cancer.