PGC-1β deficient mice show pro-arrhythmic ventricular phenotype secondary to mitochondrial dysfunction.399–401 In addition, cardiomyocyte Na+ ionic currents in the age-dependent murine PGC-1β model of ventricular arrhythmia are reduced.402 Compared to WT, the protein expressions of the Na+ channel in murine PGC-1-/- atria are also reduced.403 These changes suggest potential roles of PGC-1β in cardiac electrophysiology and ion channel changes. Here, PPARGC1B is linked to Ventricular arrhythmia.