PPARGC1A and cancer: It remarkably decreases the level of PGC-1α, which in turn markedly suppresses the elevated expression of vimentin and recovers the expression of E-cadherin in HG-induced OVCAR-3 cells.611 Additionally, isoliquiritigenin, a common herb used in traditional Chinese medicine, inhibits the expression of PGC-1α at protein level and enhances ROS accumulation in gastric cancer cells, but PGC-1α overexpression partly reverses the inhibition of ISL on cell viability.612 On the other hand, bouchardatine (an alkaloid derived from B. Neurococca) suppresses cancers via PGC-1α activation.