AD, featured by progressive impairment in cognition, emotion, language, and memory in older population, is an irreversible, multifactorial, and age-related neurodegenerative disease.437 A putatively fatal etiological hypothesis is the accumulation of Aβ.438 Importantly, there are complicated and direct links between PGC-1α and Aß. Here, PPARGC1A is linked to Alzheimer disease.