Mechanistically, PGC‐1α inhibits the expression of c-Myc through an ERRα-dependent manner and ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme for polyamine synthesis, further regulating polyamine biosynthesis and prostate cancer aggressiveness.343 These results support that PGC-1α-ERRα functions as a tumor-repressive transcriptional complex through modulating metabolic events. The gene discussed is ESRRA; the disease is Familial prostate cancer.