PPARGC1A and ovarian carcinoma: Overexpression of PGC-1α in human epithelial ovarian cancer (OC) cell line Ho-8910 induces apoptosis through the coordinated regulation of Bcl-2 and Bax expression, However, this effect is partially hindered by the PPARγ antagonist GW9662 and suppression of PPARγ.109 Additionally, downregulated PGC-1α levels increase the expression of β-secretase, a key enzyme involved in amyloid-β (Aβ) production.