PPARGC1A and acute kidney injury: Kidney ischemia-reperfusion injury (IRI), universally occurring in renal transplantation, shock, trauma, and urologic and cardiovascular surgery, is a severe common clinical event leading to rapid kidney dysfunction and AKI.494 After 24 h of kidney IRI, the renal PGC-1α expression is downregulated and PGC-1α-/- mice exhibit worsened renal function, increased fat accumulation, and more severe tubular injury.