Contactin-associated protein-like 2 (CNTNAP2) gene has been associated with autism, as both rare and common variations have been identified in patients with autism spectrum disorder (ASD).1,2 The Cntnap2 knockout (KO) mouse exhibits autistic phenotypes in communication, social activity, and repetitive behaviors, along with pathological changes in neurodevelopment,3 and it has been widely used as an animal model for ASD study.4–8 However, the mechanism underlying the role of CNTNAP2 in autism remains elusive. The gene discussed is CNTNAP2; the disease is autism.