Consistently, full-length CNTNAP2 was reduced to 39.42 ± 6.65% (p = 0.0028) by ADAM10, 21.13 ± 3.73% (p = 0.0005) by ADAM17, and 51.53 ± 15.48% (p = 0.0104) by furin, while CTFα2 was increased to 3.04 ± 0.27 and 8.09 ± 1.89 (p = 0.002) folds, and CTFf was elevated to 4.87 ± 1.81 (p = 0.041) folds by corresponding proteases in mouse neuroblastoma Neuro-2a (N2a) cells (Supplementary Fig. 1d, e). The gene discussed is ADAM10; the disease is neuroblastoma.