Notably, I79T corresponding to an ASD-associated I1253T mutation was found in a family with two autism patients.2 I79T significantly inhibited C79 generation, only reaching 1.29 ± 0.32 and 4.55 ± 1.21 folds upon ADAM10/17 overexpression (Fig. 2d, e). This evidence concerns the gene ADAM10 and autism.