In addition, the mutation reduced microgliosis in tauopathy mice, and single-nucleus RNA sequencing (snRNA-seq) in these transgenic mice revealed that the R136S mutation is associated with increased disease-protective subpopulations of neurons, astrocytes and microglia and decreased subsets of oligodendrocytes, astrocytes, and microglia linked to disease, suggesting that it may play a role in mitigating APOE4-related tauopathy. The gene discussed is APOE; the disease is tauopathy.