To this end, we monitored the protein–protein interaction (PPI) of c-MYC with TBP and with TRRAP using in situ proximity ligation assays (isPLAs) in the human neuroblastoma cell line SH-SY5Y, which constitutively overexpresses c-MYC and is a well-established model for c-MYC activity in tumorigenesis41,42. Here, MYC is linked to neuroblastoma.