As EBV-infected GlialCAM370–389-specific B cells were found to drive MS development, the EBV-specific HLA-E-restricted CD8+ T cell subgroup actively kill this specific group of B cells, and the host HLA-E*0103/0103 genotype was found connecting with even stronger cytotoxic effect. The gene discussed is HLA-E; the disease is myeloid sarcoma.