As specific subgroups of NK cells and CD8+ T cells were identified suppressing the GlialCAM370–389-specific autoimmunity and various host genetic or infectious factors could impair their function and influence the risk of MS, to evaluate how these factors contributing to the risk of MS, Vietzen et al. comprehensively analyzed the individual or group contributions of factors to MS in this study (Fig. 1b). Here, CD8A is linked to myeloid sarcoma.