In accordance with these observations, the expression of key HCC glucose transporters (slc2a1, slc2a2 and slc2a3), as well as of key glycolytic enzymes (hk2, gpi, pfk, aldoa, pkm2) was strongly up regulated in ChREBP overexpressing tumors (Fig. 6l and Supplementary Fig. 9a). This evidence concerns the gene HK2 and hepatocellular carcinoma.