Consistent with ChREBP-activated Gln conversion to Glut by GLS to support HCC cell growth, Gln deprivation or 6-Diazo-5-oxo-L-norleucine (DON)-induced GLS inhibition severely impaired ChREBP-driven cell proliferation (Fig. 8c and Supplementary Fig. 11e). This evidence concerns the gene MLXIPL and hepatocellular carcinoma.