GPR133, a member of mod2 and mod3 networks, was differentially methylated between AD cases and controls lacking ε4 (P = 6.4 × 10−6) and significantly associated with Braak stage (P = 5.8 × 10−6) and CERAD score (P = 4.6 × 10−6) (Table 1 and Supplementary Table 2). Here, ADGRD1 is linked to Alzheimer disease.