NQO1 and cancer: To improvethe cancer-selective uptake, theranostic agent 32b, composedof an SN-38 moiety linked to indolequinone and an integrin-selectivepeptide as a cancer-targeting unit was prepared.187 Theranostic agent 32b exhibited preferentialuptake in αvβ3 integrin-positivecancer cells with presumed DT-diaphorase-mediated reduction servingto release the active SN-38 and produce 50–70% cancer cellgrowth inhibition in a human cervical carcinoma (KB) cell line.