Li andco-workers devised a novel NTR-activatable NIR PS (119), which features an intrinsic ER-targeting capability and low oxygen-depletiontype I photosensitivity, endowing ERPS with highly efficientphototoxicity against cancer cells under both normoxic and hypoxicconditions.388 As depicted in Figure 64, 119-Im was constructed by caging its hydroxyl group with a 2-nitroimidazole-basedtriggering group as a recognition site for NTR. The gene discussed is NTSR1; the disease is cancer.