PTGS2 and cancer: The probe was encapsulated into folate-decoratedsilica nanoparticles that were further decorated with covalently attachedGOX enzymes to give the nanoreactor F-GOX@NR.160 Once internalized into folate-positive cancer cells asthe result of receptor-mediated endocytosis, the nanoreactor F-GOX@NRconsumes glucose to generate H2O2 via GOX catalysis.Celecoxib tagged SN-38 in its inactive form, binds to COX-2, whichfacilitates its accumulation within the cytoplasm.