ALB and neoplasm: Yoonet al. developed a theranostic probe by combining the water-solublephthalocyanine derivative PcN4 with AQ4N to improve PDT and immunotherapy.565 PcN4 can specifically bind with albumin invivo to form supramolecular complexes, which endows it with excellenttumor-targeting ability, fluorescence imaging, and PDT antitumor activity.Moreover, PDT induces hypoxia enhancement in a tumor, and AQ4N activationis concomitantly increased in the tumor, which further improves theantitumor activity.