The renal cell carcinoma is recognized by an extensive energy metabolism reprogramming, which is related to mutations in specific genes, including VHL, MET, BAP1, TFE3, TFEB, FLCN, MITF, FH, SDHB, SDHC, SDHD, TSC1, TSC2, PBRM1, SETD2 and KDM5C. Here, SDHC is linked to hereditary clear cell renal cell carcinoma.