CASR and neoplasm: The finding that myeloid-specific deletion of FIH alone is not sufficient to promote spontaneous tumorigenesis (Fig. 4B) nor to disturb the immune cell compositions in the spleen and liver tissues of aged mice under normal physiological conditions (SI Appendix, Fig. S4 E and F) illustrates that under the normal aging process, FIH deficiency in myeloid cells is not sufficient to induce tumor growth.