TGFB1 and B-cell non-Hodgkin lymphoma: Notably only lung, not liver or small intestine tissues of FIHΔ1-2/Δ1-2 mice showed significantly reduced expression of Tgfb (Fig. 2D; FIH+/+ 0.1329 and FIHΔ1-2/Δ1-2 0.06753, P = 0.01976), a cytokine that has been shown to induce senescence of B cell lymphoma cells (29), suggesting that FIH deficiency may generate an immune environment that favors B cell growth in the lung, consistent with pulmonary B cell lymphomas being only detected in FIH-defective mice.