ARG1 and colorectal carcinoma: When we treated BMDMs with supernatants of murine colorectal carcinoma CT26 cells, again we noted enhanced induction of Arg1 in the absence of FIH (SI Appendix, Fig. S6B; FIH+/+ vs. FIHΔ1-2/Δ1-2 0.128 vs. 0.293, P = 0.047, t test).