In addition, Wu et al. found that the SASP gene itself and the biomarker of atherosclerosis, IL-1β, induced senescence in human endothelial cells by up-regulating CUX1 and/or down-regulating SATB2, and CUX1 was found to repress SATB2 expression at the transcriptional level [182]. The gene discussed is CUX1; the disease is atherosclerosis.