MAP2K3 and Hyperglycemia: We observed that both the apical and basal dendrites of hippocampal pyramidal neurons had significantly fewer intersections in db/db mice than in db/m mice, but this hyperglycemia-induced reduction was partially reversed in db/db mice with MKK3 knockdown and subsequent overexpression of the MKK3 K329 mutant (Fig. 7G and H, both p < 0.001).