An interesting investigation by Zhang and colleagues examined the dysregulated molecular pathways in AMD on isolated native RPE cells from normal and AMD deceased donor eyes and found upregulated PARP-2, reduced NAD+, dysregulated AMPK/SIRT1/PGC-1α axis, and overactive mTOR in AMD-RPE [266]. Here, SIRT1 is linked to age-related macular degeneration.