IFNA1 and infection: For example, Mrp8CreHif1afl/fl G-MDSCs were enriched in cytoskeleton and leukocyte migration pathways during early infection (day 3), whereas, by day 14, IFN signaling, proinflammatory pathways, and oxidative phosphorylation were dramatically increased in various G-MDSC clusters from Mrp8CreHif1afl/fl mice compared with WT littermates.