Plasma GHR levels were recently reported to be associated with incident T2D in a large cohort study,36 and reductions in GHR levels were identified as a causal mediator of improvements in glycemia after bariatric surgery in adults with T2D.37 Prior studies showed that circulating GHR positively correlates with hepatosteatosis and adiposity in children with obesity,38 and we did find in our exploratory analyses that GHR level is positively associated with both BMI z score and fat mass in both sexes. The gene discussed is GHR; the disease is obesity due to melanocortin 4 receptor deficiency.