BHB ameliorated caspase-1 activation and IL-1β release in NLRP3-dependent diseases such as familial cold autoinflammatory syndrome, Muckle-wells syndrome, and, urate crystal-mediated peritonitis (Youm et al. 2015; Kaufmann et al. 2017). This evidence concerns the gene NLRP3 and familial cold autoinflammatory syndrome.