In a murine model of PD, the presence of histone 3 lysine 27 trimethylation (H3K27me3) repressive mark in nuclear factor-erythroid 2-related factor 2 (Nrf2) promoter region suppressed its expression and enhanced inflammasome associated proteins such as NLRP3, ASC, cleaved caspase 1 as well as ROS generation (Cai et al. 2020). Here, NFE2L2 is linked to Parkinson disease.