More than 90 genetic variants of the NLRP3 gene, most of which are autosomal dominant missense point mutations in exon 3 that codes for the NATCH domain, have been related to the characteristic symptoms of cryopyrin-associated periodic syndrome (CAPS) (Touitou et al. 2004; Masters et al. 2009). Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.