In addition, arresting NLRP3 inflammasome by administration of MCC950 blocked Isoproterenol-induced cardiac dysfunction by suppressing cardiomyocyte senescence (Shi et al. 2022) and ameliorated heart failure (HF) in obese mice by improving the cardiometabolic dysfunction (Wang et al. 2022a). The gene discussed is NLRP3; the disease is heart failure.