Intriguingly, deactivating NLRP3 inflammasome by BHB lowered osteolysis via repressing osteoclast differentiation and function (Wu et al. 2022), alleviated cisplatin-induced acute kidney injury in mice and human proximal tubular epithelial cell line (HK-2) (Luo et al. 2022b), mitigated anxiety in post-traumatic stress disorder rodent model (PTSD) (Yamanashi et al. 2020), protected against CUS-induced depressive- and anxiety-related behaviors (Yamanashi et al. 2017) and depression (Kajitani et al. 2020). This evidence concerns the gene NLRP3 and major depressive disorder.