As previously discussed (Baillie et al. 2017) the neighbouring TNIP1 gene (also known as ABIN3) encodes a more obvious regulator of inflammation located in the IRGM genomic region and regulatory variation in this gene has been detected in patients with systemic lupus erythematosus (Raj et al. 2016). This evidence concerns the gene TNIP3 and systemic lupus erythematosus.