TNIP1 and systemic lupus erythematosus: As previously discussed (Baillie et al. 2017) the neighbouring TNIP1 gene (also known as ABIN3) encodes a more obvious regulator of inflammation located in the IRGM genomic region and regulatory variation in this gene has been detected in patients with systemic lupus erythematosus (Raj et al. 2016).