Although further functional analyses such as manipulation of Rnf20 and/or Rps6 using targeted treatments (e.g., antisense oligonucleotides that inhibit Rps6 in high expression strains or drugs that target these pathways) are needed to examine changes in pain sensitivity and cognition‐related phenotypes, our findings provide further insights into the molecular mechanisms involved in the crosstalk between pain sensitivity and cognitive function, and could be beneficial for prevention, clinical diagnosis and management of pain‐related neurodegenerative diseases. Here, RPS6 is linked to neurodegenerative disease.