ACKR3 and cancer: This pathway plays a role in a variety of biological processes, such as metabolism, inflammation, cell growth, proliferation, exercise, and cancer progression,64, 65 and has also been implicated in the regulation of chronic post‐surgical pain by down‐regulating the CXCR7/PI3K/Akt signaling pathway and inducing the A1 phenotype transformation of reactive astrocytes.66