Furthermore, our results revealed that PBMT reduced the number of cleaved‐Caspase 3 and TUNEL‐positive endothelial cells in both bEnd.3 cell line and in rat brain, providing evidence that PBMT exerts a protective effect on cerebral vessels by inhibiting endothelial cell apoptosis in both in vitro and in vivo stroke models. This evidence concerns the gene CASP3 and stroke disorder.