UBE2C and glomerulonephritis: Analysis of genes of the SASP Reactome and the Fridman senescence genes were also enriched in podocytes of mice treated with DOCA (Table 3) and included ubiquitin-conjugating enzyme E2C (Ube2c, increased 6-fold) that decreases mitotic cyclins thereby limiting cell cycle progression (41) and interleukin 1A (Il1a, increased 5.6-fold), which increases in podocytes in human glomerulonephritis (42).