The current study was designed following the results of preclinical work in which TMZ-induced upregulation of CA in GBM with low MGMT protein, or a methylated MGMT promoter, via a mechanism involving BCL-3-mediated resistance to TMZ.10 Given that ACZ blocks CA activity, it was hypothesized that the addition of ACZ could sensitize tumor cells to TMZ-induced cell death. The gene discussed is BCL3; the disease is glioblastoma.