The epithelium-specific ETS (ESE) transcription factors ELF3, ELF5, and EHF have been shown to be important regulators of epithelial tissue homeostasis and cancer in multiple tissues such as the gastrointestinal tract (esophagus, large and small intestine, and stomach), salivary gland, bladder, liver and prostate for ELF3, salivary gland, breast and bladder for ELF5 and salivary gland, esophagus, vagina, prostate, colon, skin, bladder, cornea, and breast for EHF (60–63). The gene discussed is ELF3; the disease is cancer.