However, sustained activation of JAK2/STAT3 signaling had been found in many solid tumors, such as breast cancer, which promoted solid tumorigenesis, tumor growth, angiogenesis, host immune evasion, apoptosis resistance, carcinogenesis, and metastasis (Yu et al., 2009; Mengie Ayele et al., 2022; Rah et al., 2022). This evidence concerns the gene STAT3 and neoplasm.