It had been demonstrated that inhibition of MDR1/ABCB1 or MRP1/ABCC1 in the ABC transporter protein family could reverse doxorubicin resistance in tumor cells including osteosarcoma (Tsang et al., 2003; Sampson et al., 2019; Gerardo-Ramirez et al., 2022; Packeiser et al., 2023). This evidence concerns the gene ABCB1 and osteosarcoma.