HDAC4 and osteosarcoma: The key genes targeted by miR-506-3p were acquired through the cytoHubba plug-in, including STAT3, RAC-beta serine/threonine-protein kinase (AKT2), B-cell lymphoma 2-like 11 (BCL2L11), Myocyte enhancer factor 2A (MEF2A), Recombinant superoxide dismutase 2 (SOD2), Frataxin (FXN), and Histone deacetylase 4 (HDAC4) (Figure 4B), which are hub target genes that may be involved in regulating osteosarcoma development and the molecular mechanisms of chemoresistance.