As a confluence of many oncogenic signaling pathways, the activation of signal transducer and activator of transcription 3 (STAT3) could induce aberrant expression of genes associated with tumor cell proliferation, differentiation, apoptosis, and chemo-resistance, and thus promoted tumor transformation, causing poor prognosis in patients (Barre et al., 2007; Hu et al., 2019). Here, STAT3 is linked to neoplasm.