It suggested that miR-506-3p might be able to reverse chemoresistance to doxorubicin in drug-resistant osteosarcoma cells by inhibiting the phosphorylation of JAK2 and the expression of total STAT3 protein in drug-resistant osteosarcoma cells and inhibiting the over-activation of JAK2/STAT3 signaling pathway. This evidence concerns the gene STAT3 and osteosarcoma.