Echocardiography revealed that RTN3 overexpression triggered a notable decrease in systolic function and LV dilatation, as evidenced by decreased ejection fraction (EF) and fractional shortening (FS) and increased left ventricular internal dimension at systolic phase (LVIDs) and left ventricular internal dimension at diastolic phase (LVIDd), respectively (Figure S2C). The gene discussed is RTN3; the disease is Vascular dilatation.