Furthermore, disulfidptosis activity also showed tight correlations with tumors at scRNA‐seq, and pairs, such as MIF_CD74_CD44, MIF_CD74_CXCR4, MDK_NCL, and APP_CD74, might be potential targets in disulfidptosis‐related tumor microenvironment. The gene discussed is CXCR4; the disease is neoplasm.