Divalent metal transporter 1 (DMT1), ferroportin, and metal tolerance protein 1 (MTP1), transporters responsible for the absorption of iron in the intestines and its entry into the bloodstream, and hephaestin, which catalyzes the oxidation of ferrous ions to ferric ions during this process, are key regulators of iron metabolism that should be investigated further to determine if they are altered in diabetes. This evidence concerns the gene SLC11A2 and diabetes mellitus.