Since the increase in phosphorylated AKT by DNA damage stress was observed not only in clear cell carcinoma cell lines but also in cell lines of other histological subtypes (Figures 3B, C, Supplementary Figure S3), the activation of VEGFR-PI3K/AKT axis might be independent of PI3KCA mutation. The gene discussed is KDR; the disease is clear cell adenocarcinoma.