HIF-1α is a transcription factor that is expressed in response to decreased cellular oxygen partial pressure and activated to participate in angiogenesis, glycolysis, and regulation of vascular tone (151) The cellular adaptive response to hypoxia is mediated by hypoxia-inducible factor-1α, and hyperglycemia leads to decreased stability and low transcriptional potency of the HIF-1α protein in response to hypoxia (152), which also leads to a pseudo-hypoxic state that activates HIF-1α activity to adapt to hypoxia (153). This evidence concerns the gene HIF1A and Hyperglycemia.