By screening T2DM patients who underwent renal biopsy, 96 (38.71%) in the DN group and 152 (61.29%) in the non-diabetic renal disease (NDRD) group, it was found that DR was prevalent in 79 (82.3%) and 12 (7.9%), respectively, suggesting that diabetic patients without retinopathy were the most likely to develop NDRD, which suggests that clinically, some DN patients have no DR may be because clinically some patients diagnosed with DN did not undergo renal biopsy, and some patients with NDRD combined with IgE, for example, were included. Here, IGHE is linked to liver dysplastic nodule.