The results showed that grade-A embryos in PCOS-induced mice treated with RA (0.5 μg/μl body weight) (group 5), FGF2 (10 μg/kg FGF2 body weight) (group 6), and RA (0.5 μg /μl body weight) plus FGF2 (10 μg/kg FGF2 body weight) (group 7) had a significant increase compared to group 2 (P˂0.05). This evidence concerns the gene FGF2 and polycystic ovary syndrome.