GPT and Nephropathy: In our study, the elevated renal function-related indexes (Scr, Bun, FBG, UP, TG, TC, ALT, and AST) in db/db mice were all reduced after crocin administration, indicating that crocin can improve the renal function of db/db mice, which is also consistent with the previous report that crocin can improve the indexes of liver and kidney damage (24, 25).