This inverse correlation between mTOR activation and autophagic activity suggests that enhancing Beclin1 signaling can suppress mTOR activation, thereby sustaining autophagy even under severe sepsis conditions, Beclin1 and mTOR had an inseparable relationship in ALI, Beclin1 also acted as the connection of autophagy and apoptosis (39). Here, BECN1 is linked to Sepsis.