Crocetin administration to 1-methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced gastric adenocarcinoma (AGS) rats inhibited proliferation, induced apoptosis, suppressed Bcl-2, and increased regulation of Bax gene expression as well as increasing lactate dehydrogenase and anti-oxidant agent activity. This evidence concerns the gene BAX and gastric adenocarcinoma.