IL4 and asthma: Administration of C. sativus extract with dexamethasone in guinea pigs model of ovalbumin (OVA)-induced asthma increased IFN-γ level, had a stimulatory effect on T-helper 1 cells, and decreased IL-4 production or had an inhibitory effect on T-helper 2 cells leading to improved Th1/Th2 balance (180).