These effects have been observed in the context of lung diseases, specifically in terms of antitussive properties (184), relaxation of the tracheal smooth muscle, stimulation of β2-adrenoceptors, inhibition of histamine (H1) receptors in the tracheal smooth muscle (185, 227), as well as anti-inflammatory and immunomodulatory activities (4). This evidence concerns the gene HRH1 and lung disorder.