Outside of the liver, HMG-CoA reductase is also used in the production of ubiquinol, a substrate used in cellular energy production, and in post-translational protein prenylation.45 The impact of inhibiting HMG-CoA reductase in these cellular processes is thought to contribute to the development of symptoms such as myopathy and hyperglycaemia. This evidence concerns the gene HMGCR and Hyperglycemia.