We then used logistic regression to construct a risk diagnostic model for TSE disease grouping related to lipid metabolism, where the diagnosis score was calculated as follows: diagnosis score = (−64.748046) * expression (ALOX12B) + 99.234770 * expression (CBS) + (−22.507586) * expression (CPT1C) + 22.629042 * expression (DAGLB). The gene discussed is ALOX12B; the disease is human prion disease.