For example, Pérez-Valenzuela et al. (2023) examined biomarkers related to mood and anxiety disorders that include protein kinase B (Akt), glycogen synthase kinase-3 (GSK-3), BDNF, mTOR, D1, and D2 receptor in nucleus accumbens (NAc) and PFC of rats that consumed THC: CDB. Here, AKT1 is linked to anxiety disorder.