KCNMA1 and paroxysmal nonkinesigenic dyskinesia: For instance, a KCNMA1 knock-out mouse exhibits motor impairments and suffers from learning difficulties (Typlt et al., 2013), whereas paroxysmal non-kinesigenic dyskinesia is observed in patients with gain-of-function channelopathies of BK channels (Miller et al., 2021).