DHCR7 and Smith-Lemli-Opitz syndrome: For example, Smith–Lemli–Opitz syndrome (SLOS), an inborn error in cholesterol synthesis resulting from mutations in the 7-dehydrocholesterol reductase (DHCR7) gene, manifests as developmental delays, abnormal neural development, and atypical peripheral lipid metabolism (Bukelis et al., 2007; Porter, 2008).