Recent studies showed that an infection of the highly virulent ASFV strain led to the reduction of distinct T-cell subsets to some degree, except for CD4+CD8+ T cells in domestic pigs (Huhr et al., 2020), whereas the moderate virulent ASFV strain induced an increase in CD8α+ and CD4+CD8α+ αβ T cells and delayed the proliferation of CD8α+ T cells in domestic pigs (Schafer et al., 2021). This evidence concerns the gene CD4 and infection.