[41,42] found that VC severity correlated with decreased serum levels of miR-125b-2-3p and mir 378a-3p and the miRNA/mRNA pair miR-378a-30/SULF1 in combination with traditional clinical features appears to be useful for improved diagnosis and classification of the severity of uremic VC in patients with kidney failure. This evidence concerns the gene SULF1 and kidney failure.