Its antioxidant mechanisms include not only direct scavenging of ROS but also augmentation of endogenous antioxidant levels.[200] Moreover, RES can decelerate neuroblast apoptosis and mitigate motor dysfunction induced by 6‐hydroxydopamine in PD rats through activation of the phosphoinositide 3‐kinase (PI3K)/AKT signaling pathway.[201] In addition to these mechanisms, RES demonstrates anti‐inflammatory and antioxidant properties, contributing to the amelioration of motor and cognitive dysfunctions in mice with PD. Here, AKT1 is linked to Parkinson disease.