Mice with Siah1α knockdown and SR3029 administration had the slowest tumor growth, but had no effect on body weight (Fig. 8B–D and Fig. S9D,E), concomitant with increased protein level of AXIN1 and decreased expression of Wnt target genes (CyclinD1, Axin2) (Fig. 8E–G). Here, AXIN1 is linked to neoplasm.