However, the probable most relevant use of a CSF assay for caspase-6 cleaved tau is to detect non-phospho-tau pathology in AD as it seems that neurons with D13 tau are abundant in AD and only partially overlap with phospho-tau in the same neurons [7], making detection of caspase-6 cleaved tau relevance for diagnostic and therapeutic uses. This evidence concerns the gene MAPT and Alzheimer disease.