CRTC1 and Insulin resistance: Nonetheless, an association between changes in the methylation level of the CREB-regulated transcription coactivator 1 (CRTC1) gene and early weight gain following psychotropic treatment initiation was shown [21], and a positive trend for increased methylation of protein kinase B (AKT2) associated with insulin resistance was observed in patients treated with atypical antipsychotics, while the opposite correlation was revealed in mood stabilizer users [22].