BDNF and Alzheimer disease: In the 3xTG-AD animal model, resveratrol decreased the neuroinflammation and accumulation of Aβ oligomers, increased the levels of neurotrophin, synaptic markers, silencing information modulators, and decreased the markers of apoptosis, autophagy, endolysosomal degradation, and ubiquitination in the brain of 3xTG-AD mice [83].