Accumulated evidence reveals that Cirbp has been implicated in different physiological and pathological processes, including cell proliferation and differentiation, cell senescence, cell survival and apoptosis, oxidative stress, DNA damage and repair, immune and inflammatory responses, telomere maintenance, circadian rhythm, spermatogenesis, and tumor formation and progression, etc [4, 10, 35, 59, 61, 73, 137, 138]. This evidence concerns the gene CIRBP and neoplasm.