Furthermore, Cirbp inhibition remarkably boosted anti‐tumor‐killing activity of hyperthermia against NPC cells and CSC‐like cells, whereas ectopic expression of Cirbp compromised tumor‐killing effect of hyperthermia on these cells, indicating that Cirbp overexpression induces hyperthermia resistance. The gene discussed is CIRBP; the disease is nasopharyngeal carcinoma.