Our results revealed that Cirbp knockdown led to significant cell viability inhibition (Fig. 4E), colony formation suppression (Fig. 4F and Fig. S7A) and tumorsphere formation inhibition (Fig. 4G and Fig. S7B), similar to those induced by hyperthermia treatment, suggesting that down-regulating Cirbp in NPC cells might mimic the stress response the cells experience when exposed to heat treatment. Here, CIRBP is linked to nasopharyngeal carcinoma.