Several lines of evidence showed that the suppression of some genes or proteins, such as telomerase catalytic subunit TERT [1], AKT signaling [75], CTGF [33], HSP70 [19, 93], HSP90 [114] and HSP27 [79] significantly boosted the effects of hyperthermia-based anti-cancer treatments. The gene discussed is HSP90AA1; the disease is cancer.