These aforementioned results clearly suggests that ectopic expression of Cirbp mostly or completely rescues hyperthermia-induced reduction in the phosphorylation levels of ATM, Chk2, p53, ATR and Chk1, which consequently reverses hyperthermia-induced reduction in DNA damage repair ability of cancer cells and increase in cell apoptosis, ultimately leading to increased thermoresistance and tumor growth (Fig. 12). Here, CHEK2 is linked to cancer.