As expected, compared to control group (i.e., LV-shSCR), in vivo Cirbp suppression by RNAi in CNE2 and HONE1-EBV cell-derived xenografts resulted in a dramatic reduction in tumor size (Fig. 7B, E), tumor volume (Fig. 7C, F) and tumor weight (Fig. 7D, G), similar to those induced by hyperthermia treatment alone (i.e., LV-shSCR + ICG) (Fig. 7B-G), indicating that down-regulating Cirbp in subcutaneous tumor xenograft formed by NPC cells mimics the stress response the cells experience when exposed to local hyperthermia treatment. The gene discussed is CIRBP; the disease is neoplasm.