More importantly, the combination treatment with Cirbp silencing and local hyperthermia (i.e., LV-shCirbp + ICG) led to the dramatic inhibition of tumor growth, as shown by substantially reduced tumor size (Fig. 7B, E), tumor volume (Fig. 7C, F) and tumor weight (Fig. 7D, G), as compared with Cirbp knockdown or hyperthermia alone. Here, CIRBP is linked to neoplasm.