In the present study, we found that the biological implications of up-regulated genes in Cirbp-expressing NPC cells plus 42 °C were significantly over-represented in GO biological processes related to DNA repair and cell cycle (Fig. 11E, F, Tables S9, S10 and S11), and KEGG pathway including p53 signaling pathway (Fig. 11, Tables S9, S10 and S12). This evidence concerns the gene TP53 and nasopharyngeal carcinoma.