Moreover, we further found that hyperthermia notably suppressed Cirbp protein expression in indicated heating-treated CNE2 and SUNE1 cells (Fig. 10E), which further validates these mentioned-above in vitro observations on the dramatically downregulated mRNA and protein expression of Cirbp in heating-treated NPC cells (Fig. 4A, B, C). This evidence concerns the gene CIRBP and nasopharyngeal carcinoma.