SOX2 and neoplasm: Finally, hyperthermia led to a slight down-regulation of indicated stem cell-related genes in tumor xenografts formed by Cirbp-expressing CNE2 cells, as compared to those in LV-Cirbp group (Fig. 9C), whereas the expression levels of stem cell-related genes (i.e., Sox2 or ABCG2) in LV-Cirbp + ICG group were slightly higher than those in LV-con + ICG group.