In order to clarify the effect of TRAF2 in the tumorigenic activity of STAMBPL1 in HCC, the effect of TRAF2 knockdown or overexpression on the carcinogenesis of STAMBPL1 stable knockdown or overexpression HCCLM3 cell line and Hep3B cell line were detected. The gene discussed is TRAF2; the disease is hepatocellular carcinoma.