These studies hinted a potential prognostic predictive value and therapeutic capacity of STAMBPL1 in malignancies, our study identify its oncogene effect on HCC, STAMBPL1 promote proliferation, invasion, and migration of HCC cells through stabilize TRAF2 via deubiquitinating K63 Ub chain activating WNT/PI3K/NF-kb signalling pathway. Here, NFKB1 is linked to hepatocellular carcinoma.