In the disorder of COAD, the correlation was also explored on the TCGA (the cancer genome atlas) database via the CIBERSORT method, and the circular plot showed that the expression of RUNX1 was significantly positively correlated with the infiltration of macrophages (P<0.001, R = 0.26) and M2 macrophages (P<0.001, R = 0.24) in COAD (Fig. 1A). Here, RUNX1 is linked to colon adenocarcinoma.