The qPCR analysis (n = 66) revealed an elevated expression of RUNX1 in tumor tissues (P < 0.0001, Fig. 1C), and the positive associations between RUNX1 mRNA and CD163 mRNA, Arg1 mRNA, CD68 mRNA, CD206 mRNA, IL-10 mRNA were observed (all P < 0.05, Fig. 1D, Supplementary Fig. 1F). The gene discussed is CD163; the disease is neoplasm.