M2 subtype TAMs are typically polarized in the presence of M-CSF, IL-4, IL-10 and IL-13, and oriented toward remodeling extracellular matrix, promoting angiogenesis, immune evasion, and promoting tumor growth and metastasis [16–23], while the M1 phenotype is induced under the influence of IFN-γ (interferon-γ), GM-CSF (granulocyte macrophage colony stimulating factor) and TLR (Toll-like receptor) agonists [24], and reportedly antitumoral and linked with better prognosis in CRC patients [25]. This evidence concerns the gene CSF2 and neoplasm.