In order to further figure out the effect of CRC associated M2 macrophages on tumor angiogenesis, we cultured the HUVECs in the aforementioned HCT116 RUNX1OE/THP-1 co-culture-derived CMs with or without anti-hPDGF-BB antibody (20 ng/ml), and conducted the cell proliferation assay. Here, CFB is linked to neoplasm.