EPAS1 and nonpapillary renal cell carcinoma: To elucidate the specific interaction of HIF-2α and autophagy, sequencing HIF-2α knockdown RCC cell line 786-O and ccRCC tissue data, TCGA-KIRC, three independent ccRCC Gene Expression Omnibus (GEO) gene sets, and the five remaining autophagy-related genes based on their GO database annotations were used to screen the potential target (Fig. 1C).