PIGF and hypertensive disorder: In such conditions, which usually happen in the last trimester of pregnancy, there is the release of placental factors into the mother’s circulation, the imbalance of pro-angiogenic and anti-angiogenic factors (such as a decrease in placental growth factor (PIGF) and an increase in soluble fms-like tyrosine kinase-1(sFlt-1) and soluble endoglin (sEng)), and a maternal systemic endothelial disorder that leads to vascular damage and high blood pressure [3].